Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are chronic inflammatory disorders of the gastrointestinal tract. The global incidence of IBD is on the rise, partly due to the adoption of a Westernised diet. Emerging evidence suggests that gut dysbiosis, altered epithelial integrity, and defective immune responses are key factors in the pathophysiology of IBD.

Synbiotic Supplementation: A Novel Strategy

Synbiotics, a combination of probiotics and prebiotics, are gaining attention as a potential strategy for managing IBD. Probiotics are live microorganisms that confer health benefits when consumed in adequate amounts, while prebiotics are non-digestible food ingredients that promote the growth of beneficial bacteria in the gut.

A recent study investigated the effects of synbiotic supplementation containing Bacillus coagulans MTCC5856 spores (a probiotic) and whole plant sugar cane fibre (prebiotic Kfibre) in a mouse model of IBD. [], []

The mice were fed a normal diet supplemented with either B. coagulans, sugar cane fibre, or a combination of both (the synbiotic). After seven days of supplementation, colitis was induced, and the effects of the synbiotic supplementation were assessed.

Key Findings

The study found that synbiotic supplementation had several beneficial effects in the mouse model of IBD:

  • Reduced Disease Severity: Synbiotic supplementation significantly reduced the disease activity index and histological score, indicating a reduction in the severity of colitis []
  • Improved Gut Barrier Function: The synbiotic prevented the expression of tight junction proteins, which are crucial for maintaining the integrity of the gut barrier []
  • Modulated Immune Response: The synbiotic supplementation modulated the levels of key inflammatory markers, including interleukin-1β (IL-1β), interleukin-10 (IL-10), and C-reactive protein (CRP) [
  • Increased Short-Chain Fatty Acids (SCFAs): The synbiotic group showed a more extensive increase in SCFAs compared to the control group. SCFAs are important for maintaining gut health and reducing inflammation []

A landscape oriented illustration depicting Inflammatory Bowel Disease (IBD) in the human digestive system

Implications for Gut Health and IBD Management

The findings from this study suggest that synbiotic supplementation, which combines probiotics and prebiotics, could be a promising approach for managing IBD. The synergistic effects of the probiotic and prebiotic components may help to regulate the immune response, protect epithelial integrity, and reduce inflammation in the gut []

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The Role of Kfibre in Gut Health

Kfibre is a premier prebiotic product that can play a vital role in supporting gut health. Prebiotics like Kfibre serve as food for beneficial gut bacteria, promoting a healthy gut microbiome. Incorporating Kfibre into your diet can help enhance the effects of probiotics and contribute to overall gut health and well-being.


Synbiotic supplementation, combining probiotics and prebiotics, shows promise as a strategy for managing IBD and promoting gut health. The combination of Bacillus coagulans spores and whole plant sugar cane fibre has demonstrated protective synergistic effects in a mouse model of IBD. Incorporating prebiotic products like Kfibre into your diet can further support a healthy gut microbiome and contribute to overall well-being.

– The Kfibre Team


– Shinde, T., Perera, A. P., Vemuri, R., Gondalia, S. V., Karpe, A. V., Beale, D. J., … & Stanley, R. (2019). Synbiotic Supplementation Containing Whole Plant Sugar Cane Fibre and Probiotic Spores Potentiates Protective Synergistic Effects in Mouse Model of IBD. Nutrients, 11(4), 818. [DOI: 10.3390/nu11040818](